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Health, Wellness, Exercise, Reflections:Canadian researchers to start clinical trials of HIV vaccine in January
By Hilary Roberts, Postmedia News / Vancouver Sun - Dec 21, 2011
Canadian researchers working on a vaccine to prevent HIV announced Tuesday they have received approval from the U.S. Food and Drug Administration to begin clinical trials on humans in January.
A team led by Dr. Chil-Yong Kang, a virologist at the University of Western Ontario in London, Ont., plans to start Phase 1 of clinical trials on 40 HIV-positive patients to test the safety of the vaccine.
"FDA approval for human clinical trials is an extremely significant milestone for our vaccine, which has the potential to save the lives of millions of people around the world by preventing HIV infection," Kang said in a news release.
It could be about five years before the vaccine goes on the market, Kang told Postmedia News.
The SAV001 vaccine, administered as an injection, has already gone through preliminary toxicology tests on animals. It didn't show any adverse effects or safety concerns and can be produced in large quantities, Kang said.
The vaccine is the only one under development in Canada. It's unique in that it uses a dead HIV-1 virus -- similar to vaccines used against polio and influenza -- and is genetically engineered to be non-pathogenic, meaning it won't cause HIV in recipients.
"So we infect the cells with a virus and then the infected cells will produce lots of virus and we can collect them, purify them and then inactivate them," Kang said in a video explaining the vaccine posted on the University of Western Ontario's YouTube channel Tuesday.
The cells are inactivated by chemicals and by radiation, Kang said in the video.
"(The) human body will react to this immunogen and make antibodies and proper immune responses," Kang said in the video.
Kang's team has been working with Sumagen -- a South Korean pharmaceutical company that established a Canadian branch in 2008 specifically to support development of this vaccine and has patents for SAV001 in 70 countries, including the U.S. and countries in the European Union.
Clinical trials are scheduled to take place in the U.S., where facilities are already set up, Kang said in an interview.
It should take about six months to complete Phase 1 tests and a year to evaluate the results, he said. Meanwhile, researchers can prepare for Phase 2, which is meant to measure people's immune-system response.
The second phase of clinical trials is expected to involve about 600 HIV-negative people in the high-risk category for HIV infection.
Four groups of people make up the high-risk category, including hemophiliacs, injection drug users, sex trade workers and those in the gay community with multiple sexual partners.
Researchers know the vaccine will pass toxicology tests on humans in Phase 1 because it worked on monkeys and rats without any negative effects, Kang said. They also don't expect any problems passing Phase 2.
The third phase will require about 6,000 HIV-negative people also considered to be in the high-risk category. It will test how effective the vaccine is by comparing a vaccinated and a non-vaccinated group, Kang said in the video.
Researchers can't definitively predict whether the vaccine will prevent HIV in humans until Phase 3 is complete, he said in an interview.
Through the clinical trials, researchers will determine how many injections are needed, Kang said. Two shots given one month apart worked to produce enough antibodies in animals.
Kang has been studying HIV since 1987. The first decade of his work involved understanding the molecular biology of the virus, he said. The next decade focused on developing the vaccine. Kang said he is also working toward a therapeutic vaccine to treat HIV-positive patients.
HIV, the virus that causes AIDS, can be transmitted through unprotected sex, needle-sharing and from an infected mother to her baby through pregnancy, according to Health Canada. There is currently no vaccine and no proven cure for HIV or AIDS.
Between Nov. 1, 1985 and Dec. 31, 2009, there were 69,844 positive HIV tests reported in Canada, according to the Public Health Agency of Canada's most recent surveillance report.
More than 34 million people around the world were living with HIV at the end 2010, according to the United Nations Program on HIV/AIDS.
Take Action:
- Boycott Bill O'Reilly and FOX News and their advertisers. Bill discussed a French commercial by McDonalds that was meant to show that McDonalds is Gay Friendly. Bill said what is next? Is McDonalds going to be Al-Qaida friendly as well? Imagine - Bill O'Reilly compares Gays to Al-Qaida! Further, Boycott Fox's Owner "Rupert Murcoch" and get him thrown in jail for illegal - Take Action:
political donations, corruption, greed, bribery, hacking! - Boycott Target, Best Buy, Gold's Gym - for donating money towards anti-gay political candidates/organizations. Update: (12/26/2010): Target is continuing to donate to anti-gay groups/causes/politicians. Update 03/08/11 - Lady Gaga Ends Target Partnership, Reportedly Over Target's Poor LGBT Stance. Update 3/25/2010 - Target displays their hypocrisy and Sues California Gay Rights Group for Lobbying Outside Stores. Target is attempting to block the LGBT right of free speech! STOP SHOPPING AT TARGET!!!!!!!!!!!!!!!!! Update 4/8/2011: Target lost its case to stop the LGBT from canvassing in front of their stores. A huge PR Disaster for TARGET! Perhaps Target should go out of business as they betrayed their investers and customer base. Target contributed massive funds to a politician who would like to exterminate gays. Now, Target can not stop us from Boycotting them, nor picketing, nor talking to customers near their stores; although, Target allows a anti-gay company such as the Salvation Army to stand outside their door and speak with customers and raise money. Isn't this a double standard?
- End DOMA (Defense of Marriage Act). Prevents Federal employees and Gays in the Military from gaining equal benefits. Prevents Gay Partners from gaining equal benefits.
- Pass a LGBT friendly ENDA (Employee Non-Discrimination Act). ENDA would prevent employment discrimination of LGBT workforce.
- Boycott Salvation Army as they will not hire Gays! "DO NOT DONATE TO THEM."
- BOYCOTT "Chick-fil-a" for donating money to anti-gay groups.
- BOYCOTT KOCH INDUSTRIES PRODUCTS- to include their products: Angel Soft toilet paper / Brawny paper towels / Dixie plates, bowls, napkins & cups / Mardi Gras napkins and towels / Quilted Northern toilet paper / Soft 'n Gentle toilet paper / Sparkle napkins / Vanity fair napkins / Zee napkins / Georgia-Pacific paper products & envelopes / All Georgia-Pacific lumber & building products (INVISTA Products) / Lycra / Stainmaster Carpet. The billionaire - Koch brothers are ultra republican - tea bag founders/supporters that do not support causes of the LGBT community.
- Boycott WALMART - The National Gay and Lesbian Task Force criticized Wal-Mart for denying employee benefits to same-s-x partners and for failing to prohibit discrimination based on gender identity. By comparison, the group said two other chain stores with a strong presence in New York, Costco and Walgreens, did much better.
- "Tune Out Trump", Boycott all Trump Hotel, casinos, holdings, The Apprentice and NBC Network! At CPAC, Trump said he is considering a run for president as a Republican. In a interview with the Des Moines Register, Trump added that he opposes all forms of legal recognition for gay couples, not just marriage. "They should not be able to marry," he said. So why does NBC keep the Apprentice when Donald Trump has stated he may run for president? After making racist remarks about Obama and recv'g public backlash, Trump decided not to run for president after NBC renewed his awful TV Show. How can NBC re-new the clown's show after he pulled such hateful shenanigans?
- Boycott Georgia for Execution of Troy Davis @ 11:08 EST, Sep 21, 2011:
Former US President and Former GA Gov. Jimmy Carter felt that TROY DAVIS should not be executed and deserved a re-trial. The Former Director of the FBI felt that TROY DAVIS Was Not Guilty! Do not drive through Goergia as it is dangerous. Do not fly via Atlanta. For your safety -Do not travel to GA. TELL YOUR COMPANY NOT TO PARTICIPATE IN A CONVENTION IN GA! "Georgia Executes Innocent People!"
And Now, Our War of the Fittest!
This group is called "Peckers Pics." The English - slang definition of "pecker" is to pluck at the truth. Therefore, we peck at items such as Gay Men's Health, Male Fitness, Gay (LGBT) Politics & Issues. In this section you may peck at each photo in order to decide the winner of the "war of the fittest!" Whereas, you should select the "Male Athlete" that may inspire you to exercise and "get fit!" Warning: This may stoke you!
Your participation in discussion of health / news articles - appearing in this message is greatly appreciated.
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You Decide!
Santa Speedo Run, Boston; Dec 10, 2011
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Santa Speedo Run, Boston; Dec 10, 2011
Gingrich to gay man: Vote for Obama
by Shawna Shepherd and Ashley Killough - (CNN) - Dec 12/21/2011
Asked how he plans to engage the gay community in his bid for president, Newt Gingrich on Tuesday told a voter he wouldn't be the right choice for those basing their decision on the issue of same-sex marriage.
"If that's the most important (issue) to you, then you should be for Obama," Gingrich told Scott Arnold, a man who identified himself as gay.
"Okay. I am, but thank you," Arnold replied.
The comment ended a rather cordial exchange between the two at a campaign stop in Oskaloosa, Iowa.
Arnold, an adjunct professor at William Penny University, approached the former speaker, asking Gingrich how he would sway voters who disagreed with him on same-sex marriage.
"How do you plan to engage and get the hope of gay Americans and those who support them?" Arnold asked.
Gingrich replied saying he doesn't expect to get the backing from voters solely focused on changing the definition of marriage.
"And I accept that that's a reality," Gingrich said.
Gingrich has frequently taken a conservative line on the issue. Last week, he signed a pledge with the National Organization for Marriage, promising, among many things, to back a constitutional amendment defining marriage between a man and woman.
"On the other hand, for those for whom it's not the central issue in their life if they care about job creation, if they care about national security, if they care about a better future for the country at large-then I think I'll get their support," Gingrich said.
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Home Depot tells hate group what it can do with its anti-gay petition
Dec 20, 2011 - Hannibal - By Pat Cunningham
Three cheers for the corporate poohbahs at Home Depot, who have TOLD the bigots of the American Family Association to peddle their hatred elsewhere:
Executives at The Home Depot gave a cool reception to representatives of the anti-gay hate group American Family Association at the company's annual shareholder's meeting in Atlanta this week.
The AFA recently called for a nationwide boycott against The Home Depot because it says the home improvement retailer continues to "promote the homosexual agenda."
Important Notice: Our ObamaBiden2008 Group works hand - in - hand with Peckers PICS (Both groups were co-created to work with each-other). To prevent duplication of articles and questions, all members of this group are urgently recommended to join ObamaBiden2008. We have the LGBT boycott list and discuss end of DADT, etc... There are 3 gay teen suicides in the USA - daily! There are Hate crimes against gay people. There are gay people who are fired over their sexual identity. There are gay people who died for our cause! These groups are focused towards Yahoo Members who sincerely care about LGBT rights and are interested in Gay Mens Health! Most important, we have a most critical election in 2012 that shall determine the future of LGBT rights and our health care (as many suffer from pre-existing illness)! Please Join Now!